Зміни кишкового мікробіому як важливий фактор ризику розвитку метаболічних захворювань

С. М. Ткач, О. С. Ларін, А. В. Підаєв

Анотація


В огляді висвітлено сучасні уявлення про роль кишкової мікробіоти та її геному в розвитку таких метаболічних захворювань як ожиріння та цукровий діабет. Показано, що кишкова мікробіота впливає на зміни енергетичного балансу (підвищення отримання енергії з нутрієнтів) та імунітету (сприяння розвитку запалення та аутоімунних процесів), що призводять до метаболічної дисфункції, зокрема, до ожиріння, резистентності до інсуліну або його дефіциту. Розглянуто конкретні зміни складу кишкової мікробіоти та її функцій у пацієнтів з ЦД 1 та 2 типу, а також з ожирінням. Зроблено висновок, що кишкова мікробіота відіграє важливу роль в посиленні захисного кишкового бар'єру та регуляції запалення, а вплив на її характерні зміни, що є патофізіологічними особливостями ЦД 1 та 2 типу, сьогодні розглядається як важлива загальна ціль для майбутніх превентивних підходів при цьому захворюванні.

Ключові слова


кишкова мікробіота; кишковий дисбіоз; ожиріння; цукровий діабет

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Посилання


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DOI: https://doi.org/10.24026/1818-1384.1(57).2017.96971

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