Цитологічні особливості медулярного раку щитоподібної залози

В. Г. Хоперія, Н. І. Белемець, О. O. Гузь


A retrospective review of 17 cases of histologically confirmed medullary thyroid carcinoma was conducted. Certain cytologic features, such as eccentric nuclei, neuroendocrinelike nuclei, nucleoli, binucleation and multinucleation, ill-defined cytoplasmic borders, and a clean background were frequantly present. The authors found that MTC could be adequately diagnosed by fine needle aspiration, despite the frequent cytomorphologic variations, based on a set of features consistently present in majority of cases included in this study.

Ключові слова

fine-needle aspiration; medullary thyroid carcinoma; cytologic features

Повний текст:



Rosai J. Thyroid gland / Rosai and Ackerman's surgical pathology. – St. Louis: Mosby, 2004. – P. 515-594.

Bose S., Kapila K., Verma K. Medullary carcinoma of the thyroid: a cytological, immunocytochemical and ultrastructural study // Diagn Cytopathol – 1992. – Vol.8 – P. 28-32. https://doi.org/10.1002/dc.2840080107

Boi F., Maurelli I., Pinna G. et al. Calcitonin measurement in wash-out fluid from fine needle aspiration of neck masses in patients with primary and metastatic medullary thyroid carcinoma // J. Clin. Endocrinol. Metab. – 2007. – Vol.92. – P. 2115-2123. https://doi.org/10.1210/jc.2007-0326

Collins B.T., Cramer H.M., Tabatowski K. et al. Fine needle aspiration of medullary carcinoma of the thyroid: cytomorphology immunocytochemistry and electron microscopy // Acta Cytol. – 1996. – Vol. 39. – P. 920-930.

Kini S.R., Miller J.M., Hamburger J.I., Smith M.J. Cytopathologic neuroendocrine chromatin and plasmacytoid appearfeatures of medullary carcinoma of the thyroid // Arch. Pathol. Lab. Med. – 1984. – Vol.108. – P. 156-159.

Forrest C.H., Frost F.A., de Boer W.B. et al. Medullary carcinoma of the thyroid: Accuracy of diagnosis of fine-needle aspiration cytology // Cancer. – 1998. – Vol.84. – P. 295-302. https://doi.org/10.1002/(sici)1097-0142(19981025)84:5<295::aid-cncr5>3.0.co;2-j

Пристатейна бібліографія ГОСТ

DOI: https://doi.org/10.24026/1818-1384.4(37).2011.86426

Creative Commons License
Ця робота ліцензована Creative Commons Attribution-NonCommercial 4.0 International License.

© Клінічна ендокринологія та ендокринна хірургія.

ISSN: 1818-1384 (Print), e-ISSN: 2519-2582, DOI: 10.24026/1818-1384.

При копіюванні активне посилання на матеріал обов'язкове.

Flag Counter