Передопераційна гормональна терапія місцево поширеного раку молочної залози

І. Б. Щепотін; О. С. Зотов; М. Ф. Анікусько; І. І. Любота; Р. В. Любота

doi:10.24026/1818-1384.4(37).2011.86405

Автор(и)

І. Б. Щепотін Національний медичний університет імені О.О. Богомольця, Київ, Україна
О. С. Зотов Національний медичний університет імені О.О. Богомольця, Київ, Україна
М. Ф. Анікусько Київський міський клінічний онкологічний центр, Київ, Україна
І. І. Любота Київський міський клінічний онкологічний центр, Київ, Україна
Р. В. Любота Національний медичний університет імені О.О. Богомольця, Київ, Україна

DOI:

https://doi.org/10.24026/1818-1384.4(37).2011.86405

Ключові слова:

breast cancer, neoadjuvant hormone therapy, antiestrogens, aromatase inhibitors

Анотація

Endocrine therapy for locally advanced breast cancer (LABC) has more than a100-year history. Efficiency of its use in adjuvant therapy confirmed by the results of many randomized trials, however, as neoadjuvant antihormonal drug therapy induction drugs are rarely used. The results of many randomized trials on the efficacy of neoadjuvant hormonal ER + and/or ER + breast cancer in postmenopausal women indicate a high response rate from the tumor which allows to achieve objectives neoadjuvant therapy in 40-60% of patients. Optimal drugs for neoadjuvant hormonotherapy are aromatase inhibitors of the third generation (letrozole, anastrozole, exemestane) daily for 3-4 months. Preoperative endocrine therapy development aimed at identifying additional factors (besides the presence of ER and/or RP) which define a positive response from the tumor to treatment and individualize this treatment and maximize clinical outcomes.

Біографії авторів

І. Б. Щепотін, Національний медичний університет імені О.О. Богомольця, Київ

I. Shchepotin

О. С. Зотов, Національний медичний університет імені О.О. Богомольця, Київ

A. Zotov

М. Ф. Анікусько, Київський міський клінічний онкологічний центр, Київ

N. Anikusko

І. І. Любота, Київський міський клінічний онкологічний центр, Київ

И.И. Любота

Р. В. Любота, Національний медичний університет імені О.О. Богомольця, Київ

R. Lubota

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