DOI: https://doi.org/10.24026/1818-1384.1(34).2011.86138

Зміни глікемії під впливом цукрознижувальних засобів у щурів зі стрептозотоциновим діабетом на тлі висококалорійної дієти

О. П. Кіхтяк

Анотація


Effects of sensitizers (Metformin, Pioglitazone) and stimulator of insulin secretion (Glimepiride) in Fat-Fed Streptozotocin rats were studied. It was discovered that Metformin in dose of 500 mg/kg and Pioglitazone in dose of 30 mg/kg in comparison with Glimepiride in dose of 1 mg/kg per day affect carbohydrate metabolism in Fat-Fed Streptozotocin male Wistar rats. Metformin decreases fasting glucose level, and Pioglitazone more than Metformin is able to descent HbA1c in compare with the control group. Fat-Fed Streptozotocin model which supposes insulin resistance proves high affectivity of sensitizers.

Ключові слова


Streptozotocin; Fat-Fed diet; insulin resistance; Metformin; Pioglitazone; Glimepiride

Повний текст:

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Посилання


Данилова Л.А., Лопатина Н.И. Колориметрический метод определения гликозилированных гемоглобинов. // Лаб. дело. – 1986. – №5. – С. 281-283.

Atkinson L.L., VcDonald-Dyck C., Benkoczi C., Finegood D.T. Effect of chronic rosiglitazone, metformin and glyburide treatment on beta-cell mass, function and insulin sensitivity in mZDF rats. // Diabetes Obes Metab. – 2008. – Vol. 10, №9. – P. 780-790. https://doi.org/10.1111/j.1463-1326.2007.00811.x

Bailey C.J., Bagdonas A., Rubes J, McMorn S.O., Donaldson J., Biswas N., Stewart M.W. Rosiglitasone/metformin fixed-dose combination compared with uptitrated metformin alone in type 2 diabetes mellitus: a 24-week, multicenter, randomized, double-blind, parallel-group study // Clin. Ther. – 2005. – Vol. 27(10). – P. 1548-1561. https://doi.org/10.1016/j.clinthera.2005.10.012

Cheng J.T., Huang C.C., Liu I.M, Tzeng T.F., Chang C.J. Novel Mechanism for Plasma Glucose-Lowering Action of Metformin in Streptozotocin-Induced Diabetic Rats // Diabetes. – 2006. – Vol. 55. – P. 819-825. https://doi.org/10.2337/diabetes.55.03.06.db05-0934

Costa S., Goncales A., Areas A. Morgabel R.G. Effects of Metformin on QT and QTc Interval Dispersion of Diabetic Rats // Arq. Bras. Cardiol. – 2008. – Vol. 90(4). – P. 254-260. https://doi.org/10.1590/s0066-782x2008000400004

Gaikwad A.B., Viswanad B., Ramarao P. PPAR gamma agonists partially restores hyperglycemia induced aggravation of vascular dysfunction to angiotensin II in thoracic aorta isolated from rats with insulin resistance // Pharmacol. Res. – 2007. – Vol. 55(5). – P. 400-407. https://doi.org/10.1016/j.phrs.2007.01.015

Larsen P.J., Jensen P., Sorensen R.V. Differential influences of peroxisome proliferators-activated receptors gamma and alpha on food intake and energy homeostasis // Diabetes. – 2003. – Vol. 52(9). – P. 2249-2259. https://doi.org/10.2337/diabetes.52.9.2249

Matsumoto T., Noguchi E., Ishida K., Kobayashi T., Yamada N., Kamata K. Metformin normalizes endothelial function by suppressing vasoconstrictor prostanoids in mesenteric arteries from OLETF rats, a model of Type 2 diabetes // Am. J. Physiol. Heart Circ. – 2008. – Vol. 18. – P. 112-118. https://doi.org/10.1152/ajpheart.00486.2008

Matsumoto T., Noguchi E., Kobayashi T., Kamata K. Mechanism underlying the chronic pioglitazone treatment-induced improvement in the impaired endothelium-dependent relaxation seen in aortas from diabetic rats // Free Radic. Biol. Med. – 2007. – Vol. 42(7). – P. 993-1007. https://doi.org/10.1016/j.freeradbiomed.2006.12.028

Matsuura K., Mori Y., Kitahara Y., Miura K., Mine T., Tajima N. Differences in insulin secretion in portal blood following acute administration of glimepiride and glibenclamide: a study in OLETF rats // Diabetes. – 2003. – Vol. 52, Suppl. 1. – P. A126.

Mori Y., Ojima K., Fujimori Y., Aoyagi I., Kusama H., Yamazaki Y., Kojima S., Shibata N., Itoh Y., Tajima N. Effects of mitiglinide on glucose-induced insulin release into the portal vein and fat-induced triglyceride elevation in prediabetic and diabetic OLEFT rats // Endocrine. – 2006. – Vol. 29(2). – P.309-315. https://doi.org/10.1385/endo:29:2:309

Okamoto T., Kanemoto N., Ohbuchi Y. Characterization of STZ-induced Type 2 Diabetes in Zucker Fatty Rats // Exp. Anim. – 2008. – Vol. 57(4). – P. 335-345. https://doi.org/10.1538/expanim.57.335

Pathan A.R., Viswanad B., Sonkusare S.K., Ramarao P. Chronic administration of pioglitazone attenuates intracerebroventricular streptozotocin induced-memory impairment in rats // Life Sci. – 2006. – Vol. 79(23) – P. 2209-2216. https://doi.org/10.1016/j.lfs.2006.07.018

Reed M.J., Meszaros K., Entes L.J., Claypool M.D., Pinkett J.G., Gadbois T.M., Reaven G.M. A new rat model of type 2 diabetes: the fat-fed, streptozotocin-treated rat // Metabolism. – 2000. – Vol. 49(11). – P. 1390-1394. https://doi.org/10.1053/meta.2000.17721

Srinivasan K., Viswanad B., Asrat L, Kaul C.L., Ramarao P. Combination of high-fat diet-fed and low-dose streptozotocin-treated rat: a model for type 2 diabetes and pharmacological screening // Pharmacol. Res. – 2005. – Vol. 52(4). – P. 313-320. https://doi.org/10.1016/j.phrs.2005.05.004

Tessary P., Tiengo A. Metformin treatment of rats with diet-induced overweight and hypertriglyceridemia decreases plasma triglyceride concentration, while decreasing triglyceride and increasing ketone body output by the isolated perfused liver // Acta Diabetol. – 2008. – Vol. 45. – P. 143-145. https://doi.org/10.1007/s00592-008-0032-0

Verma S., Yao L., Dumont A.S., McNeill J.H. Metformin treatment corrects vascular insulin resistance in hypertension // Lippincott Williams & Wilkins. – 2000. – Vol. 18(10). – P. 1445-1450. https://doi.org/10.1097/00004872-200018100-00012

Waisundara V.Y., Hsu A., Huang D., Tan B.K. Scutellaria baicalensis Enhances the Anti-Diabetic Activity of Metfomin in Streptozotocin-Induced Diabetic Wistar rats // Am. J. Clin. Med. – 2008. – Vol. 36(3). – P. 517-540. https://doi.org/10.1142/s0192415x08005953

Yajima K., Shimada A., Hirose H., Kasuga A., Saruta T. "Low dose" metformin improves hyperglycemia better than acarbose in type 2 diabetics // The Review of Diabetic Studies. – 2004. – Vol. 1, №2. – P. 89-94. https://doi.org/10.1900/rds.2004.1.89


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