Зміни глікемії під впливом цукрознижувальних засобів у щурів зі стрептозотоциновим діабетом на тлі висококалорійної дієти

О. П. Кіхтяк

doi:10.24026/1818-1384.1(34).2011.86138

Автор(и)

О. П. Кіхтяк Львівський національний медичний університет імені Данила Галицького, Львів, Україна

DOI:

https://doi.org/10.24026/1818-1384.1(34).2011.86138

Ключові слова:

Streptozotocin, Fat-Fed diet, insulin resistance, Metformin, Pioglitazone, Glimepiride

Анотація

Effects of sensitizers (Metformin, Pioglitazone) and stimulator of insulin secretion (Glimepiride) in Fat-Fed Streptozotocin rats were studied. It was discovered that Metformin in dose of 500 mg/kg and Pioglitazone in dose of 30 mg/kg in comparison with Glimepiride in dose of 1 mg/kg per day affect carbohydrate metabolism in Fat-Fed Streptozotocin male Wistar rats. Metformin decreases fasting glucose level, and Pioglitazone more than Metformin is able to descent HbA1c in compare with the control group. Fat-Fed Streptozotocin model which supposes insulin resistance proves high affectivity of sensitizers.

Біографія автора

О. П. Кіхтяк, Львівський національний медичний університет імені Данила Галицького, Львів

O. Kikhtyak

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