Вплив метаболічного синдрому на перебіг раку молочної залози

І. Б. Щепотін; О. С. Зотов; І. І. Любота; Р. В. Любота

doi:10.24026/1818-1384.1(34).2011.86073

Автор(и)

І. Б. Щепотін Національний медичний університет імені О.О. Богомольця, Київ, Україна
О. С. Зотов Національний медичний університет імені О.О. Богомольця, Київ, Україна
І. І. Любота Київський міський клінічний онкологічний центр, Київ, Україна
Р. В. Любота Національний медичний університет імені О.О. Богомольця, Київ, Україна

DOI:

https://doi.org/10.24026/1818-1384.1(34).2011.86073

Ключові слова:

breast cancer, metabolic syndrome, risk factors

Анотація

A total of 100 patients aged 27 to 82 years (56±12) who underwent treatment for breast cancer (BC) in clinical of oncology department of the National Medical University named after AA Bogomolets on the basis of the surgical department of the Kyiv City Oncology Hospital in 2008. Patients were divided into two groups – experimental and control. In the experimental group was the 64 women who have breast cancer diagnosed and the metabolic syndrome (MS), and in the control group – 36 women, breast cancer patients without the metabolic syndrome. Found that the presence of MS in patients associated with bad prognosis of breast cancer.

Біографії авторів

І. Б. Щепотін, Національний медичний університет імені О.О. Богомольця, Київ

I. Schepotin

О. С. Зотов, Національний медичний університет імені О.О. Богомольця, Київ

A. Zotov

І. І. Любота, Київський міський клінічний онкологічний центр, Київ

I. Lyubota

Р. В. Любота, Національний медичний університет імені О.О. Богомольця, Київ

R. Lyubota

Посилання

World Health Organisation. Steward B.W., Kleihues P., editors // World Cancer Report. – Lyon. – IARC Press. – 2003.

Agnoli C., Berrino F., Abagnato C.A., Muti P., Panico S., Crosignani P., Krogh V.

Metabolic syndrome and postmenopausal breast cancer in the ORDET cohort: a nested case-control study // Nutr. Metab. Cardiovasc. Dis. – 2010. – Vol. 20, № 1. – P. 41-48. https://doi.org/10.1016/j.numecd.2009.02.006

Morimot, L.M., White E., Chen Z., Chlebowski R.T., Hays J., Kuller L., Lopez A.M., Manson J., Margolis K.L., Muti P.C., et al. Obesity, body size, and risk of postmenopausal breast cancer: the Women's Health Initiative (United States) // Cancer Causes Contr. – 2002. – Vol. 13, № 5. – P. 741-751. https://doi.org/10.1023/a:1020239211145

Folsom A.R., Kaye S.A., Prineas R.J., Potter J.D., Gapstur S.M., Wallace R.B. Increased incidence of carcinoma of the breast associated with abdominal adiposity in postmenopausal women // Am. J. Epidemiol. – 1990. – Vol. 131, № 5. – P. 794-803. https://doi.org/10.1093/oxfordjournals.aje.a115570

Furberg A.S., Veierod M.B., Wilsgaard T., Bernstein L., Thune I. Serum high-density lipoprotein cholesterol, metabolic profile, and breast cancer risk // J. Natl. Cancer Inst. – 2004. – Vol. 96, №15. – P. 1152-1160. https://doi.org/10.1093/jnci/djh216

Peeters P.H., van Noord P.A., Hoes A.W., Fracheboud J., Gimbrere C.H., Grobbee D.E. Hypertension and breast cancer risk in a 19-year follow-up study (the DOM cohort). Diagnostic investigation into mammalian cancer // J. Hypertens. – 2000. – Vol. 18, № 3. – P. 249-254. https://doi.org/10.1097/00004872-200018030-00002

Muti P., Quattrin T., Grant B. J., Krogh V., Micheli A., Schunemann H.J., Ram M., Freudenheim J.L., Sieri S., Trevisan M., Berrino F. Fasting glucose is a risk factor for breast cancer: a prospective study // Cancer Epidemiol. Biomarkers Prev. – 2002. – Vol. 11, № 11. – P. 1361-1368.

Lipscombe L.L., Goodwin P.J., Zinman B., McLaughlin J.R., Hux J.E. Diabetes mellitus and breast cancer: a retrospective population-based cohort study // Breast Cancer Res. Treat. – 2006. – Vol. 98, № 3. – P. 349-356. https://doi.org/10.1007/s10549-006-9172-5

Pasanisi P., Berrino F., De Petris M., Venturelli E., Mastroianni A., Panico S. Metabolic syndrome as a prognostic factor for breast cancer recurrences // Int. J. Cancer. – 2006. – Vol. 119, № 1. – P. 236-238. https://doi.org/10.1002/ijc.21812

Lipscombe L.L., Goodwin P.J., Zinman B., McLaughlin J.R., Hux J.E. The impact of diabetes on survival following breast cancer // Breast Cancer Res. Treat. – 2008. – Vol. 109, № 2. – P. 389-395. https://doi.org/10.1007/s10549-007-9654-0

Irwin M.L., McTiernan A., Bernstein L., Gilliland F.D., Baumgartner R., Baumgartner K., Ballard-Barbash R. Relationship of obesity and physical activity with C-peptide, leptin, and insulin-like growth factors in breast cancer survivors // Cancer Epidemiol. Biomarkers Prev. – 2005. – Vol. 14, № 12. – P. 2881-2888. https://doi.org/10.1158/1055-9965.epi-05-0185

Peeters P.H., van Noord P.A., Hoes A.W., Grobbee D.E. Hypertension, antihypertensive drugs, and mortality from cancer among women // J. Hypertens. – 1998. – Vol. 16, № 7. – P. 941-947. https://doi.org/10.1097/00004872-199816070-00007

Josefson D. High insulin levels linked to deaths from breast cancer. // BMJ. – 2000. – Vol. 320, № 7248. – P. 1496. https://doi.org/10.1136/bmj.320.7248.1496/a

Alberti K.G., Zimmet P.Z. Definition, diagnosis and classification of diabetes mellitus and its complications. Part 1: diagnosis and classification of diabetes mellitus provisional report of a WHO consultation // Diabet. Med. – 1998. – Vol. 15. – P. 539-553. https://doi.org/10.1002/(sici)1096-9136(199807)15:7<539::aid-dia668>3.0.co;2-s

Denke M.A., Pasternak R.C. Defining and Treating the Metabolic Syndrome: A Primer from the Adult Treatment Panel III // Curr. Treat. Options. Cardiovasc. Med. – 2001. – Vol. 3, № 4. – P. 251-253. https://doi.org/10.1007/s11936-001-0087-5

Alberti K.G., Zimmet P., Shaw J. The metabolic syndrome – a new worldwide definition // Lancet. – 2005. – Vol. 366, № 9491. – P. 1059-1062. https://doi.org/10.1016/s0140-6736(05)67402-8

Alberti K.G., Eckel R.H., Grundy S.M., Zimmet P.Z., Cleeman J.I., Donato K.A., Fruchart J.C., James W.P., Loria C.M., Smith S.J. Harmonizing the metabolic syndrome: a joint interim statement of the International Diabetes Federation Task Force on Epidemiology and Prevention; National Heart, Lung, and Blood Institute; American Heart Association; World Heart Federation; International Atherosclerosis Society; and International Association for the Study of Obesity // Circulation. – 2009. – Vol. 120. – P. 1640-1645. https://doi.org/10.1161/circulationaha.109.192644

Метаболический синдром Х // В.И. Целуйко, В.А. Чернышов, Л.Т. Малая. – Х.: Гриф, 2002. – 250 с.

Executive summary of the Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III) // JAMA. – 2001. – Vol. 285, № 19. – P. 2486-2497. https://doi.org/10.1001/jama.285.19.2486

Prognostic Factors in Breast Cancer // Fitzgibbons M.D. et al. // Arch. Pathol. Lab. Med. –

– Vol. 124. – P. 966-978.

Лапач С.Н., Чубенко А.В., Бабич П.Н. // Статистика в науке и бизнесе. – К.: МОРИОН, 2002. – P. 195-207.

Berrino F., Villarini A., De Petris M., Raimondi M., Pasanisi P. Adjuvant diet to improve hormonal and metabolic factors affecting breast cancer prognosis // Ann. N. Y. Acad. Sci. – 2006. – Vol. 1089. – P. 110-118. https://doi.org/10.1196/annals.1386.023

Golden S.H., Ding J., Szklo M., Schmidt M.I., Duncan B.B., Dobs A. Glucose and insulin components of the metabolic syndrome are associated with hyperandrogenism in postmenopausal women: the atherosclerosis risk in communities study // Am. J. Epidemiol. – 2004. – Vol. 160. – P. 540-548. https://doi.org/10.1093/aje/kwh250

Kaaks R. Nutrition, hormones, and breast cancer: is insulin the missing link? // Cancer Causes Control. – 1996. – Vol. 7. – P. 605-625. https://doi.org/10.1007/bf00051703

Vona-Davis L., Howard-McNatt M., Rose D.P. Adiposity, type 2 diabetes and the metabolic syndrome in breast cancer // Obes. Rev. – 2007. – Vol. 8, № 5. – P. 395-408. https://doi.org/10.1111/j.1467-789x.2007.00396.x

Poretsky L., Cataldo N.A., Rosenwaks Z., Giudice L.C. The insulin-related ovarian regulatory system in health and disease // Endocr. Rev. – 1999. – Vol. 20. – P. 535-582. https://doi.org/10.1210/edrv.20.4.0374

Berrino F., Muti P., Micheli A., Bolelli G., Krogh V., Sciajno R., et al. Serum sex hormone levels after menopause and subsequent breast cancer // J. Natl. Cancer Inst. – 1996. – Vol. 88, № 5. – P. 291-296. https://doi.org/10.1093/jnci/88.5.291

McTernan P.G., Anwar A., Eggo M.C., Barnett A.H., Stewart P.M., Kumar S. Gender differences in the regulation of P450 aromatase expression and activity in human adipose tissue // Int. J. Obes. Relat. Metab. Disord. – 2000. – Vol. 24, № 7. – P. 875-81. https://doi.org/10.1038/sj.ijo.0801254

Sherif K., Kushner H., Falkner B.E. Sex hormone-binding globulin and insulin resistance in African-American women // Metabolism. – 1998. – Vol. 47, № 1. – P. 70-74. https://doi.org/10.1016/s0026-0495(98)90195-0

Brismar K., Hilding A., Lindgren B. Regulation of IGFBP-1 in humans // Prog. Growth Factor Res. – 1995. – Vol. 6. – P. 449-456. https://doi.org/10.1016/0955-2235(96)00006-3

Norat T., Dossus L., Rinaldi S., Overvad K., Gronbaek H., Tjonneland A., et al. Diet, serum insulin-like growth factor-I and IGF-binding protein-3 in European women // Eur. J. Clin. Nutr. – 2007. - Vol. 61. – P. 91-98. https://doi.org/10.1038/sj.ejcn.1602494

Hanaire-Broutin H., Sallerin-Caute B., Poncet M.F., Tauber M., Bastide R., Rosenfeld R., et al. Insulin therapy and GH-IGF-I axis disorders in diabetes: impact of glycaemic control and hepatic insulinization // Diabetes Metab. – 1996. – Vol. 22. – P. 245-250.

Tollet P., Enberg B., Mode A. Growth hormone (GH) regulation of cytochrome P-450IIC12, insulin-like growth factor-I (IGF-I), and GH receptor messenger RNA expression in primary rat hepatocytes: a hormonal interplay with insulin, IGF-I, and thyroid hormone // Mol. Endocrinol. – 1990. – Vol. 4, № 12. – P. 1934-1942. https://doi.org/10.1210/mend-4-12-1934

Campagnoli C., Pasanisi P., Peris C., Berrino F. Insulin-like Growth Factor-I and Breast Cancer: Epidemiological and Clinical Data // Breast Cancer: Prognosis, Treatment and Prevention. – 2008. – P. 2. https://doi.org/10.3109/9781420058734-18

Sieminska L., Wojciechowska C., Foltyn W., Kajdaniuk D., Kos-Kudla B., Marek B., et al. The relation of serum adiponectin and leptin levels to metabolic syndrome in women before and after the menopause // Endokrynol. Pol. – 2006. – Vol. 57, № 1. – P. 15-22.