Стан системи гіпофіз – надниркові залози на тлі замісної терапії рекомбінантним гормоном росту у дітей, хворих на соматотропну недостатність
DOI:
https://doi.org/10.24026/1818-1384.2(39).2012.82494Ключові слова:
children, somatotropic insufficiency, recombinant growth hormone (rhGH), the pituitary-adrenal systemАнотація
The purpose of this study was to investigate cortisol blood levels in in children with somatotropic insufficiency during rhGH – therapy. Study parameters were assessed at baseline and after 6 and 12 months of rhGH replacement. Children with somatotropic insufficiency show statistically significant decrease of blood cortisol levels during long – term rhGH – replacement. These data indicate that rhGH-replacement is associated with hypocorticism, occured during rhGH- therapy. GH-deficient patients need additional hormone replacement therapy with glucocorticoids and careful monitoring of blood cortisol level every 3 months during rhGH-replacement.
Посилання
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