Рівень комплексів антиген-антитіло у хворих на рак щитоподібної залози у ранній термін після радіойодотерапії залежно від віку

Н. М. Степура; Г. А. Замотаєва

doi:10.24026/1818-1384.3(44).2013.77769

Автор(и)

Н. М. Степура Інститут ендокринології та обміну речовин ім. В.П. Комісаренка НАМН України, Київ, Україна
Г. А. Замотаєва Інститут ендокринології та обміну речовин ім. В.П. Комісаренка НАМН України, Київ, Україна

DOI:

https://doi.org/10.24026/1818-1384.3(44).2013.77769

Ключові слова:

age, radioiodine therapy, differentiated thyroid cancer, iodine-131, circulating immune complexes

Анотація

The age is one of the important factors that modifies the effect of radiation exposure on the organism. In this connection, a study of the immune system of thyroid cancer patients of different age after radioiodine therapy – and, in particular, determination of the levels of circulating immune complexes – are of a scientific interest. The authors present data on the content of antigen-antibody complexes in 86 patients with thyroid carcinoma early after radioiodine therapy. Patients were divided into three groups: children and adolescents aged 13 to 18 years (average: 16,0±0,3); young adults aged 19 to 40 years (average: 28,4±1,02); and the oldest age group from 41 to 70 years (average: 53,8±1,4). Age-matched donors served as controls. Levels of circulating immune complexes were measured before and 6 days after receiving radioiodine. It has been established that on the eve of radioiodine therapy, in all age groups of patients the number of immune complexes was significantly higher compared to control values and almost did not differ between the groups under study. It has been shown that in short terms after iodine-131 administration, significantly increased levels of circulating immune complexes were noted only in patients aged 21 to 40 years. It would be appropriate to study the dynamics of immune complexes formation in patients of different age after radioiodine administration in order to determine possible age-related differences.

Біографії авторів

Н. М. Степура, Інститут ендокринології та обміну речовин ім. В.П. Комісаренка НАМН України, Київ

N. Stepura

Г. А. Замотаєва, Інститут ендокринології та обміну речовин ім. В.П. Комісаренка НАМН України, Київ

G. Zamotayeva

Посилання

Biological dosimetry in patients treated with iodine 131 for differentiated thyroid carcinoma / R. M. Kacher, J. D. Legal, M. Schlumberger [et al.] // J. Nucl. Med. – 1996. – №37. – P. 1860-1864.

Biologic dosimetry in thyroid cancer patients after repeated treatments with iodine-131 / R. M`Kacher, M. Schlumberger, J. D. Legal [et al.] // J. Nucl. Med. – 1998. – №39(5). – P. 825-929.

Cancer risk in thyroid cancer patients. / P. Hall, L.E. Holm, G. Lundell [et al.] // Br. J. Cancer. – 1991. – Vol. 64. – P. 159-163.

Assessment of female fertility and carcinogenesis after iodine-131 therapy for differentiated thyroid carcinoma / M.E. Dottorini, G. Lomuscio, L. Mazzucchelli [et al.] // J. Nucl. Med. – 1995. – Vol. 36. – P. 21-27.

Leukemias and cancers following iodine-131 administration for thyroid cancer / F. De Vathaire, M. Schlumberger, P. Hall [et al.] // Brit. J. Cancer. – 1997. – Vol. 75. – P. 734-739. https://doi.org/10.1038/bjc.1997.130

Ярилин А.А. Действие ионизирующей радиации на лимфоциты (повреждающий и активирующий эффекты) / А.А. Ярилин // Иммунология. – 1988. – № 5. – С. 5-11.

Cytogenetic damage after 131-iodine treatment for hyperthyroidism and thyroid cancer. A study using the micronucleus test / S. Gutierrez, E. Carbonell, P. Galofre [et al.] // Eur. J. Nucl. Med. – 1999. – Vol. 26, №12. – P. 1589-1596. https://doi.org/10.1007/s002590050499

Possible transient adaptive response to mitomycin C in peripheral lymphocytes from thyroid cancer patients after iodine-131 therapy. / G.O. Monteiro, N.G. Oliveira, A.S. Rodrigues [et al.] // Int. J. Cancer. – 2002. – Vol.102, №6. – P. 556-561. https://doi.org/10.1002/ijc.10768

Formation of micronuclei and of clastogenic factor(s) in patients receiving therapeutic doses of iodine-131 / M. Ballardin, F. Gemignani, L. Bodei [et al.] // Mutal. Res. – 2002. – Vol. 514, №1-2. – P. 77-85. https://doi.org/10.1016/s1383-5718(01)00323-0

Dainiak N. Hematologic consequences of exposure to ionizing radiation / N. Dainiak // Experimental Hematology. – 2002. – Vol. 30, №6. – P. 513-528. https://doi.org/10.1016/s0301-472x(02)00802-0

Ройт А. Иммунология / Ройт А., Бростофф Дж., Мейл Д. – Москва: Мир, 2000. – 581 c.

Association of immune complexes and plasma viral load with CD4+ cell depletoin, CD8+DR+ and CD16+ cell counts in HIV+ hemophilia patients. Implication for the immunopathogenesis of HIV-induced CD4+ lymphocyte depletion / V. Daniel, C. Susal, R. Weimer [et al.] // Immunol. Lett. – 2001. – Vol. 76, №2. – P. 69-78. https://doi.org/10.1016/s0165-2478(01)00181-x

Simple method of circulating immune complex detection in human sera by poliethylene glycol precipitation / V. Haskova, J. Koslik, I. Riha [et al.] // Immunitasforsoh. – 1978. – Bd.154, №4. – P. 399-406.

Замотаєва Г. Вміст циркулюючих імунних комплексів у хворих на диференційованный рак щитоподібної залози в процесі лікування радіойодом / Г. Замотаєва, Н. Степура // Ендокринологія. – 2009. – Т. 2, №2. – С. 188-193.