Патогенетична роль кишкового дисбіозу в розвитку ожиріння та цукрового діабету 2 типу
DOI:
https://doi.org/10.24026/1818-1384.3(55).2016.77658Ключові слова:
кишкова мікробіота, дисбіоз, цукровий діабет 2 типу, ожирінняАнотація
У статті висвітлені сучасні погляди на роль кишкового дисбіозу в розвитку ожиріння та цукрового діабету 2 типу. Зокрема, ці метаболічні розлади чітко асоційовані із зниженням різноманіття кишечної мікробіоти та підвищенням числа штамів, що найбільш ефективно добувають енергію з продуктів харчування. Такі відмінності у складі кишкової мікробіоти можуть бути застосовані як ранні діагностичні маркери розвитку цукрового діабету 2 типу у пацієнтів підвищеного ризику. Трансплантація кишкової мікробіоти від худих чоловічих донорів реципієнтам з метаболічним синдромом приводить до значного поліпшення чутливості до інсуліну в поєднанні з підвищенням різноманіття кишечної мікробіоти, в тому числі особливих бутират-продукуючих бактеріальних штамів, що володіють позитивними метаболічними ефектами.
Посилання
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