Патогенетична роль кишкового дисбіозу в розвитку ожиріння та цукрового діабету 2 типу

О. С. Ларін, С. М. Ткач, О. С. Тимошенко, Т. Ю. Юзвенко

Анотація


У статті висвітлені сучасні погляди на роль кишкового дисбіозу в розвитку ожиріння та цукрового діабету 2 типу. Зокрема, ці метаболічні розлади чітко асоційовані із зниженням різноманіття кишечної мікробіоти та підвищенням числа штамів, що найбільш ефективно добувають енергію з продуктів харчування. Такі відмінності у складі кишкової мікробіоти можуть бути застосовані як ранні діагностичні маркери розвитку цукрового діабету 2 типу у пацієнтів підвищеного ризику. Трансплантація кишкової мікробіоти від худих чоловічих донорів реципієнтам з метаболічним синдромом приводить до значного поліпшення чутливості до інсуліну в поєднанні з підвищенням різноманіття кишечної мікробіоти, в тому числі особливих бутират-продукуючих бактеріальних штамів, що володіють позитивними метаболічними ефектами. 


Ключові слова


кишкова мікробіота; дисбіоз; цукровий діабет 2 типу; ожиріння

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DOI: https://doi.org/10.24026/1818-1384.3(55).2016.77658



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