Модифікація кишкової мікробіоти і фекальна трансплантація як перспективні методи лікування ожиріння, інсулінорезистентності і цукрового діабету 2 типу
DOI:
https://doi.org/10.24026/1818-1384.2(54).2016.75861Ключові слова:
ожиріння, інсулінорезистентність, цукровий діабет 2 типу, фекальна трансплантаціяАнотація
Поширеність ожиріння та цукрового діабету 2 типу у світі невпинно зростає. Останні дослідження породили принципово нову перспективу відносно того, що кишечна мікробіота може відігравати значну роль у розвитку цих метаболічних порушень. Зміни в складі кишечної мікробіоти сприяють системному запаленню, що є характерною ознакою ожиріння та інсулінорезистентності. Таким чином, важливо розуміти реципрокні взаємовідносини між складом кишечної мікробіоти та «метаболічним» здоров’ям з тим, щоб запобігти розвитку хвороби. Дослідження щодо фекальної трансплантації дозволили виявити ключову роль у цьому процесі бутират-продукуючих кишечних бактерій, здатних регулювати різні сигнальні каскади, що асоціюються з ожирінням, інсулінорезистентністю та цукровим діабетом 2 типу.
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