Рак щитоподібної залози фолікулярного походження: клініко-морфологічні характеристики та прогноз

О. С. Ларін, М. В. Кротевич, В. Г. Хоперія, К. О. Галахін


In this article the main histopathological features of differentiated follicular thyroid carcinoma, caracters influencing their prognosis were analysed. In all cases distant metastasis, extrathyroid invasion and age are the most significant features; histology, limitation and differentiation are then involved. The diagnosis of malignancy suspected on the fine needle aspiratuion cytology must be confirmed on the frozen sections at the time of surgery; in the main time extention and histological type can be determined and help to choose the treatment.

Ключові слова

thyroid follicular cancer; prognosis; papillary cancer; follicular cancer

Повний текст:



Akslen L.A. Prognostic importance of histologic grading in papillary thyroid carcinoma // Cancer. — 1993. — V. 72. N.9. — P. 2680-5.

Albores-Saavedra J., Gould E., Vardaman C., Vuitch F. The macrofollicular variant of papillary thyroid carcinoma: a study of 17 cases // Hum Pathol. — 1991. — N. 22[12]. — P. 1195-205.

Allo M.D., Christianson W., Koivunen D. Not all 'occult' papillary carcinomas are 'minimal' // Surgery — 1988. — N. 104. — P. 971-976.

Carcangiu M.L., Bianchi S. Diffuse sclerosing variant of papillary thyroid carcinoma. Clinicopathologic study of 15 cases // Am J Surg Pathol. — 1989. — N. 13[12]. — P. 1041-9.

Chen K.T.K., Rosai J. Follicular variant of thyroid papillary carcinoma: a clinicopathologic study of six cases // Am J Surg Pathol. — 1977. — N. 1. — P. 123-130.

Chen K.T.K. Fine-needle aspiration cytology of papillary Hurthle-cell tumors of thyroid: a report of three cases // Diagn Cytopathol. — 1991. — N. 7. — P. 53-56.

Chen K.T.K. Minute [< 1 mm] occult papillary thyroid carcinoma with metastasis //.Am J Clin Pathol. — 1989. — N. 91. — P. 746.

Cooper D.S., Doherty G.M., Haugen B.R. et al. Management Guidelines for Patients with Thyroid Nodules and Differentiated Thyroid Cancer // Thyroid. — 2006.

De Lellis R.A., Lloyd R.V., Heitz P.U., Eng C. World Health Organization Classification of tumours. Pathology and genetics of tumours of endocrine organs. IARC Press: Lyon. — 2004.

Cersosimo E. et al. "Suspicious" thyroid cytologic findings: outcome in patients without immediate surgical treatment // Mayo Clin. Proc. — 1993. — Vol.68, N4. — P. 343-348.

De Micco C., Vassko V., Henry J.F. The value of thyroid peroxidase immunohistochemistry for preoperative fine-needle aspiration diagnosis of the follicular variant of papillary thyroid cancer // Surgery. — 1999. — Vol.126, N6. — P. 1200-1204.

Hay I.D., Bergstralh E.J., Goellner J.R., Ebersold J.R., Grant C.S. Predicting outcome in papillary thyroid carcinoma: development of a reliable prognostic scoring system in a cohort of 1779 patients surgically treated at one institution during 1940 through 1989 // Surgery. — 1993. — N. 114[6]. — P. 1050-7.

Hoie J., Stenwig A.E., Kullmann G., Lindegaard M. Distant metastases in papillary thyroid cancer. A review of 91 patients // Cancer. — 1988. — N. 61[1]. — P. 1-6.

Johnson T.L., Lloyd R.V., Thompson N.W., Beierwaltes W.H., Sisson J.C. Prognostic implications of the tall cell variant of papillary thyroid carcinoma // Am J Surg Pathol. — 1988. — N. 12. — P. 22-27.

Pacini F., Cetani F., Miccoli P., Mancusi F., Ceccarelli C., Lippi F., Martino E., Pinchera A. Outcome of 309 patients with metastatic differentiated thyroid carcinoma treated with radioiodine // World J Surg. — 1994. — N. 18[4]. — P. 600-4.

Pacini F., Schlumberger M., Dralle H., Elisei R., Smit J.W., Wiersinga W. European consensus for the management of patients with differentiated thyroid carcinoma of the follicular epithelium // Eur J Endocrinol. — 2006. — N. 154[6]. P. 787-803.

Prendiville S., Burman K.D., Ringel M.D., Shmookler B.M., Deeb Z.E., Wolfe K., Azumi N., Wartofsky L., Sessions R.B. Tall cell variant: an aggressive form of papillary thyroid carcinoma // Otolaryngol Head Neck Surg. — 2000. — N. 122[3]. — P. 352-7.

Ruegemer J.J., Hay I.D., Bergstralh E.J., Ryan J.J., Offord K.P., Gorman C.A. Distant metastases in differentiated thyroid carcinoma: a multivariate analysis of prognostic variables // J Clin Endocrinol Metab. — 1988. — N. 67[3]. — P. 501-8.

Schlumberger M.J. Papillary and follicular thyroid carcinoma // N Engl J Med. — 1998. — N. 338[5]. — P. 297-306.

Shah J.P., Loree T.R., Dharker D., Strong E.W., Begg C., Vlamis V. Prognostic factors in differentiated carcinoma of the thyroid gland // Am J Surg. — 1992. — N. 164[6]. — P. 658-61.

Hay I.D., Mcconahey W.M., Goellner J.R. Managing patients with papillary thyroid carcinoma: insights gained from the Mayo Clinic`s experience of trading 2,512 consecutive patients during 1940 through 2000 // Trans. Am. Clin. Climatol. Assoc. — 2002. — Vol.113. — P. 241-260.

Hirokawa M. et al. Macrofollicular variant of papillary thyroid carcinoma — Report of a case with fine needle aspiration biopsy findings // Acta Cytol. — 1998. — Vol.42, N6. — P. 1441-1443.

Kahn N.F., Persin K.H. Follicular carcinoma of the thyroid: an evaluation of the histology criteria used for diagnosis // Pathol. Annu. — 1983. — Vol.18. — P. 221-253.

Lang W., Georgii A. et al. The differentiation of atypical adenomas and encapsulated follicular carcinomas in the thyroid gland // Virchows Arch.[A]. — 1980. — Vol.385. — P. 125-141.

Mizukami Y. et al. Diffuse follicular variant of papillary carcinoma of the thyroid // Histopathology. — 1995. — Vol.27. — P. 575-577.

VaskoV. , Gaudart J., Allasia C., Sanchenko V., Di Cristofaro J. et al. Thyroid follicular adenomas may display features of follicular carcinoma and follicular variant of papillary carcinoma // Eur. J. of Endocrinol. — 2004. — V.151. — P. 1-9.

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ISSN: 1818-1384 (Print), e-ISSN: 2519-2582, DOI: 10.24026/1818-1384.

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