PPAR-g агоністи: чи рішення про серцево-судинний ризик остаточне?

О. П. Кіхтяк


Four month treatment with pioglitazone showed statistically relevant improvement of the certain list of markers: fasting glucose, HOMA-IR index, HbA1c. We speculate that descent of fasting glucose and C-peptide elevation may indicate peripheral improvement of insulin binding capacity since insulin concentration in blood circulation decreases. Treatment with pioglitazone showed its anti-atherosclerotic abilities by dyslipidemia improvement and by markedly decrease of the C-reactive protein, a strong predictor of cardiovascular events.

Ключові слова

pioglitazone; HOMA-IR index; high density lipoproteins; C-reactive protein

Повний текст:



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ISSN: 1818-1384 (Print), e-ISSN: 2519-2582, DOI: 10.24026/1818-1384.

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