DOI: https://doi.org/10.24026/1818-1384.1(22).2008.118399

Розчинний рецептор кінцевих продуктів посиленого глікування у хворих на цукровий діабет 2-го типу: зв'язок з інсулінорезистентністю

М. Ю. Горшунська, Ю. І. Караченцев, Н. С. Краснова, Е. Йенсен, О. І. Гладких, В. В. Полторак

Анотація


31 middle-age patients with type 2 diabetes mellitus, dysglicaemia, dyslipidaemia and overweight or obesity were observed. Under renal insufficiency absence there were not reliable changes of the soluble receptor for advanced glycation end-products (sRAGE) level. However, the indirect correlations of sRAGE with hyperglycaemia, hormonal and metabolic factors of insulin resistance, iron homoeostasis and low grade inflammation parameters were found. The indirect association of sRAGE with pathogenic markers of insulin resistance and atherogenesis suggests their counteracting effect on the synthesis of the endogenous RAGE inhibitor. Strong direct correlation of sRAGE with antiatherogenic markers grounds use of this index for type 2 diabetes mellitus monitoring and diabetic vascular complications therapy.

Ключові слова


soluble receptor for advanced glycation end-products; type 2 diabetes mellitus; insulin resistance

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ISSN: 1818-1384 (Print), e-ISSN: 2519-2582, DOI: 10.24026/1818-1384.

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